Trichosporon asahii infection treated with caspofungin combined with liposomal amphotericin B.

نویسندگان

  • Matteo Bassetti
  • Francesca Bisio
  • Antonio Di Biagio
  • Ivana Pierri
  • Manuela Balocco
  • Ornella Soro
  • Mario Cruciani
  • Dante Bassetti
چکیده

1. Bonnet, R. (2003). Growing group of extended-spectrum blactamases: the CTX-M enzymes. Antimicrobial Agents and Chemotherapy 48, 1–14. 2. Mushtaq, S., Woodford, N., Potz, N. et al. (2003). Detection of CTX-M-15 extended-spectrum b-lactamase in the United Kingdom. Journal of Antimicrobial Chemotherapy 52, 528–9. 3. Baraniak, A., Fiett, J., Hryniewicz, W. et al. (2002). Ceftazidimehydrolysing CTX-M-15 extended-spectrum b-lactamase (ESBL) in Poland. Journal of Antimicrobial Chemotherapy 50, 393–6. 4. Mavroidi, A., Tzelepi, E., Miriagou, V. et al. (2002). CTX-M-3 blactamase-producing Escherichia coli from Greece. Microbial Drug Resistance 8, 35–7. 5. National Committee for Clinical Laboratory Standards (2001). Performance Standards for Antimicrobial Disk Susceptibility Tests: Approved Standard M2-A7. NCCLS, Wayne, PA, USA. 6. Tzelepi, E., Magana, C., Platsouka, E. et al. (2003). Extendedspectrum b-lactamase types in Klebsiella pneumoniae and Escherichia coli in two Greek hospitals. International Journal of Antimicrobial Agents 21, 285–8. 7. Jalaluddin, S., Devaster, J. M., Scheen, R. et al. (1998). Molecular epidemiological study of nosocomial Enterobacter aerogenes isolates in a Belgian hospital. Journal of Clinical Microbiology 36, 1846–52. 8. Olsen, J. E. (1990). An improved method for rapid isolation of plasmid DNA from wild-type gram-negative bacteria for plasmid restriction profile analysis. Letters in Applied Microbiology 10, 209–12. Journal of Antimicrobial Chemotherapy DOI: 10.1093/jac/dkh337 Advance Access publication 1 July 2004

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Use of combination therapy to successfully treat breakthrough Trichosporon asahii infection in an acute leukemia patient receiving voriconazole

Trichosporon species is an important life-threatening opportunistic systemic pathogen, especially in leukemia patients. Voriconazole is proved to be a promising agent in past decade. However, recently we observed a case of breakthrough Trichosporon asahii infection while receiving voriconazole, which calls for an alternative treatment strategy. A combination therapy of liposomal amphotericin B ...

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Two Case Presentations Infected by Trichosporon asahii and Treated with Voriconazole Successfully

Background. Trichosporon asahii is an opportunistic fungus that causes infections in immunosuppressed patients. Neutropenia developing due to malignancies is an important risk factor for fungal infection. Case Report. We present two pediatric oncology cases successfully treated with voriconazole after T. asahii infection that is known to cause fatal sepsis and invasive fungal infection. Conclus...

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In vitro activities of antifungal combinations against biofilms and planktonic forms of clinical Trichosporon asahii isolates.

Trichosporon species can cause biofilm-associated infections related to indwelling medical devices, especially intravenous catheters, and unacceptable mortality rates have been reported despite the administration of antifungal treatments (1). Trichosporon asahii can form biofilms with structured microbial communities in vitro, embedded within an extracellular matrix, with significantly increase...

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Vertebral infection with Candida albicans failing caspofungin and fluconazole combination therapy but successfully treated with high dose liposomal amphotericin B and flucytosine

A patient with Candida spondylitis failed two weeks of fluconazole combined with caspofungin, and the infection relapsed despite six weeks of liposomal amphotericin B followed by two months of fluconazole. Six months therapy with high dose liposomal amphotericin B combined with flucytosine effectively cured the patient.

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Successful treatment of breakthrough disseminated Trichosporon asahii fungemia in a patient with acute myeloid leukemia receiving itraconazole prophylaxis

We encountered a case of a 73-year-old man with acute myeloid leukemia who developed Trichosporon asahii systemic infection while on itraconazole prophylaxis during severe neutropenia. Cryptococcal antigen was useful for diagnosis. Although itraconazole was ineffective in protecting against trichosporonosis, treatment was successful with voriconazole following liposomal amphotericin B.

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عنوان ژورنال:
  • The Journal of antimicrobial chemotherapy

دوره 54 2  شماره 

صفحات  -

تاریخ انتشار 2004